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标题：Synergistic Effect over Sub-nm Pt Nanocluster@MOFs Significantly Boosts Photo-oxidation of N-alkyl(iso)quinolinium Salts
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作者：Shan-Shan Fu ; Xiu-Ying Ren ; Song Guo 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：1
页码：1-43
DOI：10.1016/j.isci.2019.100793
语种：English
出版社：Elsevier
摘要：SummaryQuinolones and isoquinolones are of interest to pharmaceutical industry owing to their potent biological activities. Herein, we first encapsulated sub-nm Pt nanoclusters into Zr-porphyrin frameworks to afford an efficient photocatalyst Pt0.9@PCN-221. This catalyst can dramatically promote electron-hole separation and1O2generation to achieve synergistic effect first in the metal-organic framework (MOF) system, leading to the highest activity in photosynthesis of (iso)quinolones in >90.0% yields without any electronic sacrificial agents. Impressively, Pt0.9@PCN-221 was reused 10 times without loss of activity and can catalyze gram-scale synthesis of 1-methyl-5-nitroisoquinolinone at an activity of 175.8 g·gcat−1, 22 times higher than that of PCN-221. Systematic investigations reveal the contribution of synergistic effect of photogenerated electron, photogenerated hole, and1O2generation for efficient photo-oxidation, thus highlighting a new strategy to integrate multiple functional components into MOFs to synergistically catalyze complex photoreactions for exploring biologically active heterocyclic molecules.Graphical AbstractDisplay OmittedHighlights•A state-of-the-art photocatalyst for preparation of bioactive (iso)quinolones•Synergistic catalysis of photogenerated e−/h+and1O2•Sub-nm Pt0.9@PCN-221 with a high efficiency of e−-h+separation and1O2generationCatalysis; Inorganic Materials; Organic Chemistry