文章基本信息

标题：Exercise-Mediated Lowering of Glutamine Availability Suppresses Tumor Growth and Attenuates Muscle Wasting
本地全文：下载
作者：Katrine S. Pedersen ; Francesco Gatto ; Bo Zerahn 等
期刊名称：iScience
印刷版ISSN：2589-0042
出版年度：2020
卷号：23
期号：4
页码：1-25
DOI：10.1016/j.isci.2020.100978
语种：English
出版社：Elsevier
摘要：SummaryGlutamine is a central nutrient for many cancers, contributing to the generation of building blocks and energy-promoting signaling necessary for neoplastic proliferation. In this study, we hypothesized that lowering systemic glutamine levels by exercise may starve tumors, thereby contributing to the inhibitory effect of exercise on tumor growth. We demonstrate that limiting glutamine availability, either pharmacologically or physiologically by voluntary wheel running, significantly attenuated the growth of two syngeneic murine tumor models of breast cancer and lung cancer, respectively, and decreased markers of atrophic signaling in muscles from tumor-bearing mice. In continuation, wheel running completely abolished tumor-induced loss of weight and lean body mass, independently of the effect of wheel running on tumor growth. Moreover, wheel running abolished tumor-induced upregulation of muscular glutamine transporters and myostatin signaling. In conclusion, our data suggest that voluntary wheel running preserves muscle mass by counteracting muscular glutamine release and tumor-induced atrophic signaling.Graphical AbstractDisplay OmittedHighlights•Reduced access to glutamine inhibits cancer growthin vitroandin vivo•Acute exercise reduces serum glutamine•Wheel running prevents muscular changes in glutamine transport and catabolic signaling•Wheel running reduces tumor growth and tumor-induced weight lossCancer; Physiology; Specialized Functions of Cells