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标题：Antimicrobial quercetin 3-O-glucoside derivative isolated from Streptomyces antibioticus strain ess_amA8
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作者：Essam Nageh Sholkamy ; Maged Sayed Ahmed ; Manal Mohamed Yasser 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：3
页码：1838-1844
DOI：10.1016/j.jksus.2020.01.026
语种：English
出版社：Elsevier
摘要：AbstractStreptomyces antibioticusstrain ess_amA8 was isolated from the insectTapinoma simrothi, and was tested for the production of compounds that inhibit the growth of microorganisms. The cultural and physiological descriptions of the strain revealed that it belonged to theStreptomycesgenus. The 16S rRNA gene from theStreptomycesisolate was sequenced, and its length was 1156 bp and it was submitted to Genbank (KF996507). According to molecular and morphological studies, the isolated strain was ultimately identified as strain ess_amA8 ofStreptomyces antibioticus. The key compound was extracted from the strain ess_amA8, which was activein vitro, against a wide range of microorganisms, such asStaphylococcus aureusATCC6538,Bacillus subtilisATCC 6633,Pseudomonas aeruginosaATCC 9027,Escherichia coliATCC-7839,Candida albicans,Fusarium moniliforme,Aspergillus niger, andAspergillus flavus. The physico-chemical property of the purified antimicrobial compound analyzed and its proposed empirical formula was C27H25O13. According to the IUPAC name, this compound was identified as 5,7-diethoxy-2-(3-methoxy-4-methylphenyl)-3-[(2R,3S,4R,5R,6S)-3,4,5,6-tetrahydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl] oxy-4H-chromen-4-one, and was a quercetin 3-O-glucoside derivative. In summary, the present study highlights the fact that the purified quercetin 3-O-glucoside antimicrobial derivative, first report to thisStreptomycessp., and it is a flavanone glycoside.
关键词：Streptomyces antibioticus;Tapinoma simrothi;Quercetin;Flavanone glycoside