文章基本信息

标题：Influence of Antibiotic-Impregnated Biomaterials on Inflammatory Cytokines
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作者：Ingus Skadiņš ; Juta Kroiča ; Ilze Salma 等
期刊名称：Proceedings of the Latvian Academy of Sciences, Section B. Natural, exact, and applied sciences, B dala. Dabaszinatnes
印刷版ISSN：1407-009X
电子版ISSN：1407-009X
出版年度：2019
卷号：73
期号：2
页码：177-184
DOI：10.2478/prolas-2019-0028
语种：English
出版社：The Academy
摘要：AbstractLocal antibiotic therapy has several advantages over systemic antibiotic treatment. Using antibiotics in local biomaterial systems can reduce the number of microorganisms that can adhere to implanted biomaterials. In thisin vitrostudy, antibacterial properties of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers were examined. The antibacterial efficiency of hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers againstStaphylococcus epidermidisandPseudomonas aeruginosawas studied by evaluating the expression of inflammatory cytokines (Interleukin-10 (IL-10), -defensin-2 and tumour necrosis factor alpha (TNF- )) in tissue surrounding implanted biomaterialsin vivo. The results of this study demonstrated that hydroxyapatite biomaterials impregnated with antibiotics and biodegradable polymers had a prolonged antibacterial effect in comparison to biomaterials without biodegradable polymers. Surrounding tissue displayed higher levels of inflammatory cytokines when implanted biomaterials had not been previously impregnated with antibiotics.
关键词：Keywordsimpregnated biomaterialsS. epidermidisP. aeruginosainterleukin-10β-defensin-2TNF-α