文章基本信息

标题：STUDY ON ENVIRONMENTAL BEHAVIOR AND DRUG-RESISTANT GENE EMISSION CHARACTERISTICS OF p-LACTAM ANTIBIOTICS IN DRUG PRODUCTION PROCESS
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作者：Jingqiong Xiao ; Xiuqin Wang ; Liming Zheng 等
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2020
卷号：29
期号：4A
页码：2975-2981
语种：English
出版社：PSP Publishing
摘要：In this paper, UPLC-MS/MS content determination method and P-lactam drug resistance gene detection method for simultaneous detection of five P-LAD in water were used to systematically study the environmental behaviors and drug resistance gene emission characteristics of five common P- LADs (ie amoxicillin, ampicillin, ceftazidime, cefotaxime, cefepime) in drug production process. The results showed that the bacteria selected from the system not only had a high proportion of resistant bacteria, but also had strong drug resistance, and the drug resistance genes had emission patterns. Finally, the research method established in this study was successfully applied to the detection of P- lactam concentration and drug resistance genes in the factory drainage system.
关键词：P-LAD;UPLC-MS/MS;environmental behavior;drug resistance gene