文章基本信息

标题：Effects of Melatonin on Some Antioxidant Enzymes in Streptozotocin-induced Diabetic Rats
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作者：Deniz ULUIŞIK ; Ercan KESKİN ; Durmuş HATİPOĞLU 等
期刊名称：Turkish Journal of Sport and Exercise
印刷版ISSN：2147-5652
出版年度：2019
卷号：21
期号：2
页码：217-222
DOI：10.15314/tsed.560865
语种：English
摘要：In this study, it was aimed to determine theeffects of melatonin application in experimentally induced diabetes. For thispurpose, thirty two adult male Wistar Albino rats were used. Animals in controlgroup were not any treatment. Melatonin group animals received 50 mg/kgmelatonin intraperitoneally in daily for eight weeks. Diabetes was induced bysubcutaneous injections of streptozotocin at dose of 40 mg/kg for two days as asingle dose per day in diabetes group animals. Animals in Diabetes+Melatoningroup were made diabetic by streptozotocinin the same way and then these animals received 50 mg/kg melatoninintraperitoneally in daily for eight weeks. In bloodsamples taken from all animals, insulin, glucose, HbA1c, MDA, GSH, SOD were determined. The insulin level in diabetesgroup was lower than control group, while blood glucose level was higher(p<0.05). Melatonin treatment to diabetic animals resulted in significantlydifferences in these parameters compared to diabetes group (p<0.05). HbA1cin diabetes group was higher than control group (p<0.05). Melatoninapplication to diabetic animals significantly decreased HbA1c compared to diabetesgroup (p<0.05). In diabetes group, GSH and SOD levels were found to be lowerthan control group, whereas MDA level were high (p<0.05). The changes in GSHand SOD levels with melatonin application to diabetic animals were notimportant compared to diabetes group, while MDA level was significantly reduced(p<0.05). As a result, we concluded that the melatonin treatment toexperimentally induced diabetic rats obviously improved the some negativechanges in metabolic parameters resulting from diabetes.
关键词：Diabetes;melatonin;antioxidant;HbA1c