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标题：The Protective Effect of Melatonin on Plasma Lipid Profile in Rats with Cerulein-induced Acute Pancreatitis
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作者：Ercan KESKİN ; Deniz ULUIŞIK
期刊名称：Turkish Journal of Sport and Exercise
印刷版ISSN：2147-5652
出版年度：2019
卷号：21
期号：2
页码：332-336
DOI：10.15314/tsed.541829
语种：English
摘要：ABSTRACTThe objective of this study was to assessmentthe effect of melatonin on lipid profile in rats with experimentally inducedacute pancreatitis. In this study, 32 adult, male, healthy Wistar Abino rats wereused. Group I animals was no applied.Group II animals was intraperitoneally administered 50 mg/kg melatoninper rat twice for two hours intervals. Animalsof group III received two intraperitoneal injections of cerulein (50 µg/kg and25 µg/kg bw, respectively) at two hoursintervals. Animals of group IVreceived two intraperitoneal injections of cerulein (50 µg/kg and 25 µg/kg bw,respectively) at two hours intervals andthe rats received an intraperitoneal injection of 50 mg/kg melatonin 30 minbefore each cerulein injection. After 12hours from the last cerulein injection, total cholesterol, triglyceride, LDL, HDLlevels was determined. In this study,experimentally induced acute pancreatitis resulted in significantly increase inlevels of total cholesterol, triglyceride and LDL (p<0.05), while HDL levelsignificantly decreased compared with control group level (p<0.05). Pretreatment of melatoninto the rats with acute pancreatitis importantly reduced triglyceride and LDLlevels compared to pancreatitis group (p<0.05). In conclusion, melatonin pretreatment may alleviatethe abnormalities in plasma lipid profile caused by acute pancreatitis.
关键词：Cerulein;melatonin;acute pancreatitis;lipid profile