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标题：Serial blood volume estimation in rabbits using trivalent chromium – An exploratory study
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作者：Prathap Moothamadathil Baby ; Pramod Kumar ; Rajesh Kumar 等
期刊名称：MethodsX
印刷版ISSN：2215-0161
电子版ISSN：2215-0161
出版年度：2019
卷号：6
页码：1068-1071
DOI：10.1016/j.mex.2019.05.009
语种：English
出版社：Elsevier
摘要：Graphical abstractDisplay OmittedAbstractThough often used in cardiac intensive monitoring set up, simultaneous evaluation of several variables like CVP, PCWP, SVV and hTEE for fluid volume resuscitation (especially when capillary permeability is major problem than cardiac performance) is a major challenge in many ICU setups. Therefore, repetitive determination of blood volume by trivalent chromium [51Cr (III)] as a direct single variable method may be a near ideal method during fluid volume resuscitation in cases where capillary permeability is a major problem (e.g. Burns). Hence, in the present article the repeatability and reliability of51Cr (III) method in New Zealand white rabbits was explored. Mean blood volume values of initial measurement were 195.66 ± 47.30 ml or 89.81 ± 17.88 ml/kg body weight. Repeated mean blood volume values, measured after 1 h, was 181.98 ± 53.16 ml or 83.68 ± 22.09 ml/kg body weight. The average difference between the initial and repeated measurements was 10.93 ml (95% CI −3.33, 25.19 ml), which is not statistically significant (P = 0.128). The method using51Cr (III) for repeat blood volume measurements after sixty minutes in rabbits is a reliable method.•Rapid•Repeatable•Reliable
关键词：Blood volume;Trivalent chromium;New Zealand white rabbits;Repeat blood volume;Capillary leakage;Volume shift;Sepsis