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标题：GC–MS analysis for compound identification in leaf extract of Lumnitzera racemosa and evaluation of its in vitro anticancer effect against MCF7 and HeLa cell lines
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作者：G. Eswaraiah ; K. Abraham Peele ; S. Krupanidhi 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：1
页码：780-783
DOI：10.1016/j.jksus.2019.01.014
语种：English
出版社：Elsevier
摘要：AbstractThe aim of present study is to analyze and separate bioactive constitutes of methanol leaf extract fromLumnitzera racemosaby Gas chromatography–Mass spectroscopy (GC–MS) and further to test forin vitroanticancer activity on MCF 7 and HeLa cancer cells using MTT assay. GC–MS analysis ofL.racemosaleaf extract showed the presence of different bioactive compounds mainly: furfurals and fatty acids. The bioactive compounds present inL. racemosarevealed significant cytotoxic activity against MCF 7 with IC50value, 46.098 µg/mL and HeLa cells with IC50value of 59.497 µg/mL. The leaf extracts ofL. racemosahas high anticancer activity on MCF 7 cells in comparison with HeLa cell lines.
关键词：Lumnitzera racemosa;Bioactive compounds;Mangrove species;Methanol;GC–MS