文章基本信息

标题：Identification of bioactive compounds in leaf extract of Avicennia alba by GC-MS analysis and evaluation of its in-vitro anticancer potential against MCF7 and HeLa cell lines
本地全文：下载
作者：G. Eswaraiah ; K. Abraham Peele ; S. Krupanidhi 等
期刊名称：Journal of King Saud University - Science
印刷版ISSN：1018-3647
出版年度：2020
卷号：32
期号：1
页码：740-744
DOI：10.1016/j.jksus.2018.12.010
语种：English
出版社：Elsevier
摘要：AbstractThe current study focused on GC-MS analysis for identification of bioactive compounds in leaf extract of mangrove plant,Avicennia albaand the leaf extract ofAvicennia albawas tested for cytotoxicity against MCF 7 and HeLa cell lines. The spectral properties (GC-MS) of each separated compound were determined and found the different compounds namely terpenoids, di-terpene alcohols, tri-terpenes and phenolic compounds. GC-MS analysis proved that the leaf extract ofAvicennia albacontain a high content of phenolic compounds. The methanol extract showed potent cytotoxicity against Human breastadeno carcinoma (MCF7) and HeLa cell lines, the viability of cancerous cells is reduced to 44.68% for MCF 7 and 35.89% for HeLa cells. The high anticancer activity was found against HeLa cell lines than MCF 7 cell lines.
关键词：Anticancer;HeLa cells;MCF 7 cells;MTT assay;GC-MS