文章基本信息

标题：Period - control in a coupled system of two genetic oscillators for synthetic biology ⁎
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作者：Eleni Firippi ; Madalena Chaves
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2019
卷号：52
期号：26
页码：70-75
DOI：10.1016/j.ifacol.2019.12.238
语种：English
出版社：Elsevier
摘要：Biological complex mechanisms with oscillatory behavior are often modeled by high dimensional nonlinear ODEs systems, which makes the analysis and understanding the dynamics of the system difficult. In this work, we consider two reduced models that mimic the oscillatory dynamics of the cell cycle and the circadian clock, and study their coupling from a synthetic biology perspective. To improve the performance and robustness of the oscillatory dynamics in a living cellular environment, we consider the problem of augmenting the parameter region admitting periodic solutions. Moreover, we study the capacity for mutual period regulation and control of the coupling between the two reduced oscillators.
关键词：Keywordscoupled oscillatorsperiod responsereduced modelssynthetic biologydynamic behavior