文章基本信息

标题：Modeling Population Structure Under Hierarchical Dirichlet Processes
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作者：Lloyd T. Elliott ; Maria De Iorio ; Stefano Favaro 等
期刊名称：Bayesian Analysis
印刷版ISSN：1931-6690
电子版ISSN：1936-0975
出版年度：2019
卷号：14
期号：2
页码：313-339
DOI：10.1214/17-BA1093
语种：English
出版社：International Society for Bayesian Analysis
摘要：We propose a Bayesian nonparametric model to infer population admixture, extending the hierarchical Dirichlet process to allow for correlation between loci due to linkage disequilibrium. Given multilocus genotype data from a sample of individuals, the proposed model allows inferring and classifying individuals as unadmixed or admixed, inferring the number of subpopulations ancestral to an admixed population and the population of origin of chromosomal regions. Our model does not assume any specific mutation process, and can be applied to most of the commonly used genetic markers. We present a Markov chain Monte Carlo (MCMC) algorithm to perform posterior inference from the model and we discuss some methods to summarize the MCMC output for the analysis of population admixture. Finally, we demonstrate the performance of the proposed model in a real application, using genetic data from the ectodysplasin-A receptor (EDAR) gene, which is considered to be ancestry-informative due to well-known variations in allele frequency as well as phenotypic effects across ancestry. The structure analysis of this dataset leads to the identification of a rare haplotype in Europeans. We also conduct a simulated experiment and show that our algorithm outperforms parametric methods.
关键词：admixture modeling; Bayesian nonparametrics; hierarchical Dirichlet process; linkage disequilibrium; population stratification; single nucleotide polymorphism data; MCMC algorithm.