文章基本信息

标题：EFFECT OF CARBON TETRACHLORIDE (CCl_4) AND ELLAGIC ACID ON RAT ERYTHROCYTE G6PD, 6PGD, GR, GST AND TrxR ENZYME ACTIVITIES
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作者：Mahire Bayramoglu Akkoyun ; H Turan Akkoyun
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2019
卷号：28
期号：9
页码：6779-6785
语种：English
出版社：PSP Publishing
摘要：In presented study, in vivo effects of the important polyphenol ellagic acid and CCl_4 compound known for its toxic effects on metabolic activity levels of some rat erythrocyte enzymes such as G6PD (glucose 6-phosphate dehydrogenase), 6PGD (6-phosphogluconate dehydrogenase), GR (Glutathione reductase), TrxR (Thioredoxin reductase) and GST (Glutathione S-transferase) were investigated. G6PD enzyme activity meaning rised in CCl_4 group and ellagic acid+CCl_4 group compared to the control group (p<0.001). 6PGD enzyme activity decreased in CCl_4 applyed group compared to control group (p<0.05). The enzyme activity level increased in ellagic acid (p<0.05) and CCl_4+ellagic acid (p<0.01) applied groups. An increase was observed in ellagic acid (p<0.001) and CCl_4+ellagic acid (p<0.001) applied groups compared to CCl_4 administered group. GST enzyme activity reduced in CCl_4 applied group compared to control group (p<0.01). GR enzyme activity decreased significantly in CCl_4 and ellagic acid groups compared to control group (p<0.05 and p<0.01). TrxR enzyme activity decreased in CCl_4 group and ellagic acid administered group compared to control group (p<0.001). A decrease in CCl_4+ellagic acid group compared to control was also observed (p<0,001).
关键词：Carbon tetra chloride;Ellagic acid;Metabolic enzyme