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标题：THE PROTECTIVE EFFECT OF LACTOBACILLUS RHAMNOSUS, LACTOBACILLUS FERMENTUM AND LACTOBACILLUS BREVIS AGAINST CISPLATIN-INDUCED HEPATIC DAMAGE IN RATS
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作者：Volkan Gelen ; Sevda Urcar Gelen ; Fikret Celebi 等
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2019
卷号：28
期号：10
页码：7583-7592
语种：English
出版社：PSP Publishing
摘要：Cisplatin, an anticarcinogenic agent, is reported to have side-effects that include hepatotoxicity. Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. Thus, the objective of this study was to investigate the protective effects of probiotic bacteria against cisplatin-induced hepatotoxicity. Spra- gue-Dawley male rats weighing 220-250g were used in the study. Fifty rodents were assigned to five groups (10 in each group). The groups received treatments for seven days. On day eight, the rats were decapitated, and blood and liver tissue were taken. When the liver tissue was assessed for oxidative stress, that in Group II was found to have significantly increased stress compared to that in the other groups (p<0.050). It was determined that serum AST, ALT, and LDH levels; the SOD activity; and the GHS levels in liver homogenates from CP- treated rats were significantly decreased when compared with the other groups (p<0.05). The MDA levels in liver homogenates from CP-treated rats were significantly increased when compared with other groups (p<0.05). Cytokine levels (IL-8, IL-lβ, and TNF-a) in the liver tissue were significantly elevated in the Group II compared to those in Group I (p<0.050). The comparative values were similar in Groups I and V. Bax and 8-OHdG cell density were significantly elevated in Group II compared to Group I, Group IV and Group V. Probiotic bacteria were observed to have a protective effect against CP- induced hepatic damage.
关键词：Cisplatin;Rat;Probiotic;Hepatotoxicity;Bax;8-OHdG