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标题：Restrictive measure for the commercialization of antimicrobials in Brazil: results achieved
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作者：Josiane Moreira da Costa ; Cristiano Soares de Moura ; Cristiane Aparecida Menezes de Pádua 等
期刊名称：Revista de Saúde Pública
印刷版ISSN：0034-8910
出版年度：2019
卷号：53
DOI：10.11606/s1518-8787.2019053000879
语种：English
出版社：Universidade de São Paulo
摘要：ABSTRACT OBJECTIVE To assess whether the incidence of hospital infection by a resistant microorganism decreased after the implementation of the restrictive measure of the National Health Surveillance Agency for the commercialization of antimicrobials. METHODS A historical cohort study of medical records of adult patients admitted to a general and public hospital from May 2010 to July 2011. A cohort was formed with patients admitted in the period before the restrictive measure for the commercialization of antimicrobials (Phase I) and a second cohort was formed with patients admitted after the implementation of the restrictive measure (Phase II). RESULTS The instantaneous risk of hospital infection by a resistant microorganism was estimated at seven by 1,000 people-time (95%CI 0.006–0.008) in Phase I, and four by 1,000 people-time (95%CI 0.003–0.005) in Phase II of the study. The differences between the survival curves in the different phases of the study and stratified by age group were also significant (p < 0.05). CONCLUSIONS The results suggest that the implementation of the restrictive measure of the commercialization of antimicrobials by the National Health Surveillance Agency reduced the incidence of hospital infection by a resistant microorganism.
关键词：enAnti-Bacterial AgentsPrescription Drug Overuse, legislation & jurisprudenceDrug Resistance, MicrobialDrug MonitoringPharmacovigilance