文章基本信息

标题：The Nanoformulations of Curcumin for Cancer Therapy: New Perspectives
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作者：Aisha H. Al-Shehri ; Ahmed M. Kabel ; Maaly A. Abd Elmaaboud 等
期刊名称：Journal of Cancer Research and Treatment
印刷版ISSN：2374-1996
电子版ISSN：2374-2003
出版年度：2019
卷号：7
期号：1
页码：21-26
DOI：10.12691/jcrt-7-1-4
语种：English
出版社：Science and Education Publishing
摘要：Curcumin is a natural yellow phenolic compound that is located in many types of herbs, especially Curcuma Lana (Turmeric). It is a natural anti-oxidant and has shown many pharmaceutical activities in the preclinical and clinical studies such as antioxidant, anti-microbial, anti-cancer and anti-alzheimer disease effects. In addition, curcumin was proven to be anti-diabetic, hepatoprotective, neuroprotective and anti-rheumatic and it also protects against thrombosis and myocardial infarction. The major limitation to the use of curcumin in clinical practice is its very low oral bioavailability. Therefore, many technologies have been developed and implemented to overcome this limitation. In this review, we discussed the latest perspectives regarding the design and development of nano-sized systems for the anti-diabetic agent curcumin, including liposomes, polymeric nanoparticles, micro-conjugates, micelles, peptide carriers, solid dispersions, cyclodextrins, emulsions and lipid nanopeptides and their role as a promising hope for cancer therapy.
关键词：curcumin; nanoformulations; cancer; perspectives