文章基本信息

标题：UPDATING THE SIGNIFICANCE OF SCREENING AND TRIAGE METHODS OF CERVICAL LESIONS – REVIEW
本地全文：下载
作者：Ruxandra STĂNCULESCU ; Vasilica BAUȘIC ; Linda CLUCERU POPA 等
期刊名称：Research and Science Today
印刷版ISSN：2247-4455
电子版ISSN：2285-9632
出版年度：2019
期号：2
页码：146-157
语种：English
出版社：RST Journal
摘要：THE IDENTIFICATION OF WOMEN HAVING OR BEING ABLE TO DEVELOP CERVICAL CANCER IS A MAJOR CONCERN WORLDWIDE EXPRESSED BY ENDEAVORS TO IMPLEMENT NEW METHODS OF SCREENING AND TRIAGE FOR PRECANCEROUS CERVICAL LESIONS (PCL). THE PRESENT WORK ENCOMPASSES RESULTS OF MANY TRIALS AND OBSERVATIONAL STUDIES PUBLISHED ON INTERNATIONAL DATABASES DURING LAST 10 YEARS. THE PURPOSE OF CURRENT STUDY IS TO HIGHLIGHT THE FEATURES OF ADVANCED BIOTECHNOLOGIES, CONCERNING THEIR CAPACITY OF LEADING TO AN EARLY RIGHT DIAGNOSIS SUPPORTING, TO COMPARE THE EFICACITY OF THESE TESTS SUCH SENSITIVITY AS SPECIFICITY, TO TRIAGE BETWEEN REGRESSIVE AND PROGRESSIVE PCL, TO HIGHLIGHT THE DIFFERENCE CONCERNING SCREENING METHODS ADOPTED BY THE NATIONAL PROGRAMMES WORLDWIDE. THE RESULTS SHOWED THAT PAP TEST IS AN EXPENSIVE METHOD, WITH HIGH LEVEL OF SUBJECTIVE ASSESSMENT AND WITHOUT POSSIBILITY OF DISCRIMINATION BETWEEN DIFERENT KINDS OF CYTOLOGIES. HUMAN PAPILLOMAVIRUS (HPV) GENOTYPE ALONE DOESN’T ALLOW TO DISTINGUISH TRANSIENT VERSUS PROGRESSIVE HPV INFECTION. IMMUNOSTAINING CYCLINE P16INK4A AND THE MORE PERFORMANT TEST, DUAL TEST P16INK4A/ KI 67 ALLOW THE TRIAGE OF CASES ABLE TO DEVELOP CANCER USED ALONE OR AS CO-TEST TO PRIMARY HPV SCREENING. PRIMARY CERVICAL SCREENING WITH HPV GENOTYPE ASSOCIATE WITH ONE OF CO-CIYTOLOGIC TEST IMPROVE THE ACCURACY OF AN EARLY DIAGNOSIS.
关键词：CERVICAL CANCER;PRECANCEROUS CERVICAL LESIONS;BIOTECHNOLOGIES;PAP TEST;HPV GENOTYPE;P16INK4A;P16INK4A/ KI 67