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标题：Evaluation of Lead Genotoxicity by Micronuclei Assay in Occupationally Lead Exposed Population
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作者：N. Chandrashekhar Reddy ; K. Rudrama Devi ; Anjana Viz 等
期刊名称：Nature, Environment and Pollution Technology
印刷版ISSN：0972-6268
出版年度：2010
卷号：9
期号：3
语种：English
出版社：Technoscience Publications
摘要：Lead, a ubiquitous element in the environment as a result of mining and industrialization,is found as a contaminant in humans. Lead is one of the heavy metals increasinglyused for the petrol additives, and for various industrial purposes such as manufactureof storage batteries, solder manufacture, printing, smelting, painting, etc. In this studythe lead genotoxicity was studied by using one of the recommended biomarker to assessenvironmental lead exposure is micronucleus assay. The blood samples were collectedfrom 50 workers and 40 aged matched controls (5mL of venous blood from each leadexposed individual in heparinized sterile bottles). The battery manufacturers showed asignificant increase in the frequency of micronuclei in comparison to that people whowere not exposed to any toxicants. The results of present investigation indicate theclastogenic nature of lead in in vivo human lymphocytes of occupationally exposedpopulation.