摘要:Subjects occupationally exposed to potential mutagens/carcinogens represent the most suitable groups forepidemiological studies aimed at assessing the risk for the individual or the offspring. Several cancer risksto humans have been detected by epidemiological studies performed in occupational settings. Theepidemiology studies have been able (a) to identify specific occupations or agents associated with the risk;(b) to verify the results of experimental studies; and (c) to test the effectiveness of changes in production orpreventive measures in decreasing risks. Reproductive epidemiology has suggested a risk of spontaneousabortions or of malformation in the offspring of workers exposed to some chemicals or occupations, but dataare often conflicting due to methodological problems. With the aim of early assessment of risk in mind, theepidemiological use of indicators of exposure or of the early effect of exposure to genotoxic agents isincreasingly applied to occupational groups. Data on the fertility and other reproductive end points in 128women beedi rollers exposed to tobacco dust were recorded by using standard questionnaire. The exposedgroup were further categorized based on duration of exposure, life style, smoking and non-smoking andsocio-economic status. The statistical analysis shows that the differences in the reproductive end pointsbetween the control and exposed groups were significant (P< 0.05).