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标题：Protective Effect of Zinc Supplementation on Renal Ischemia/Reperfusion Injury in Rat: Gender-related Difference
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作者：Fatemeh Moslemi ; Ardeshir Talebi ; Mehdi Nematbakhsh 等
期刊名称：INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE
印刷版ISSN：2008-7802
出版年度：2019
卷号：10
DOI：10.4103/ijpvm.IJPVM_279_17
语种：English
出版社：ISFAHAN UNIVERSITY OF MEDICAL SCIENCES
摘要：Background: Zinc (Zn) knows as essential microelement which prevents oxidative stress. The effect of Zn supplement on renal function parameters in rats subjected to renal ischemia-reperfusion (IR) injury was investigated. Methods: Male and female rats were subjected to renal IR with and without Zn sulfate (10 mg/kg/day for 5 days) supplementation. The kidney function markers and histology findings in Zn-treated group were compared with sham and control groups. Results: The serum levels of blood urea nitrogen and creatinine (Cr) and kidney tissue damage score were increased significantly after renal injury ( P < 0.05) gender dependently, but no alterations were observed for these markers in Zn-treated animals after renal IR injury. Cr clearance was significantly different between genders ( P < 0.05); however, Zn supplementation increased the Cr clearance and kidney nitrite level significantly in male rats ( P < 0.05). Zn also increased urine flow in female ( P < 0.05), but it did not alter urine load of Na (U NaV) and percentage of Na excretion (E Na%). Conclusions: Zn may improve renal function after IR injury gender dependently.
关键词：enGenderratsrenal ischemia-reperfusionzinc