文章基本信息

标题：An artificial pancreas based on simple control algorithms and physiological insight
本地全文：下载
作者：John Bagterp Jørgensen ; Dimitri Boiroux ; Zeinab Mahmoudi 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2019
卷号：52
期号：1
页码：1018-1023
DOI：10.1016/j.ifacol.2019.06.196
语种：English
出版社：Elsevier
摘要：AbstractWe present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.
关键词：KeywordsControl algorithmPIDFeed-forward controlRun-to-run controlDiabetesArtificial pancreas