文章基本信息

标题：A Nonovershooting Controller with Integral Action for Multi-input Multi-output Drug Dosing Control ⁎
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作者：Regina Padmanabhan ; Nader Meskin ; Clara M. Ionescu 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2018
卷号：51
期号：4
页码：60-65
DOI：10.1016/j.ifacol.2018.06.029
语种：English
出版社：Elsevier
摘要：AbstractIn this paper, a nonovershooting tracking controller is proposed for the continuous infusion of multiple drugs that have interactive effects. The proposed controller design method exploits the freedom of eigenstructure assignment pertinent to the design of feedback controllers for multi-input, multi-output (MIMO) systems. For drug dosing, a nonovershooting tracking controller restricts the undesirable side effects of drug overdosing. The proposed tracking controller is based on an estimate of the full state using a hybrid extended Kalman filter (EKF) that is used to reconstruct the system states from the measurable system outputs. An integral control action is included in the controller design to achieve robust tracking in the presence of patient parameter uncertainty. Simulation results and performance analysis of the proposed control strategy are also presented using 20 simulated patients.
关键词：KeywordsNonovershooting controlactive drug dosingbiomedical control