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标题：In vitro studies of the antileishmanial activity of the newer 2-(substitutedphenoxy)- N-[(aryl)methylidene]acetohydrazide analogues
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作者：Mohamed Jawed Ahsan ; Md Yousuf Ansari ; Praveen Kumar 等
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2016
卷号：5
期号：2
页码：119-125
DOI：10.1016/j.bjbas.2016.05.002
语种：English
出版社：Elsevier
摘要：AbstractA series of new 2-(substitutedphenoxy)-N-[(aryl)methylidene]acetohydrazide analogues (8a-n) were synthesized in search of potential therapeutics for leishmaniasis. All the compounds were characterized by infrared (IR), nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry. The compounds were further evaluated forin vitroantileishmanial activity against promastigotes ofLeishmania donovanias per the standard protocol reported elsewhere. 2-(2,4-Dichlorophenoxy)-N′-{[4-(morpholin-4-yl)phenyl]methylidene}acetohydrazide (8k) showed the most promising antileishmanial activity with IC50of 48.10 µM, free from cytotoxicity (>153.08 µM).
关键词：Acetohydrazide analogues;Antileishmanial activity;Leishmania donovani