文章基本信息

标题：FISH CHOLINESTERASES: BIOMARKERS OF NEUROTOXCITY OF SUBLETHAL EFFECTS OF CARBOSULFAN AND PARATHION IN CIRRHINUS MRIGALA
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作者：Muhammad Rafique Asi ; Zubair Ahmed ; Fahad Almisned 等
期刊名称：Fresenius Environmental Bulletin
印刷版ISSN：1018-4619
出版年度：2015
卷号：24
期号：2A
页码：565-569
语种：English
出版社：PSP Publishing
摘要：Cirrhinus mrigala was exposed to sub-lethal concentrations of carbosulfan (carbamate) and parathion (organophosphate) to study the toxic effects on acetylcholinesterases (AChE) and butyrylcholinesterases (BuChE) activity in the brain, gills, liver, kidneys, blood and flesh, compared with control samples. The fingerlings of Cirrhinus mrigala were exposed to three sub-lethal concentrations of parathion (0.041, 0.020 and 0.013 mg/L) and carbosulfan (0.098, 0.049 and 0.033 mg/L) in three replicates for 60 days. The activity of cholinesterases (AChE and BuChE) was significantly inhibited, even at the lowest exposure levels of parathion and carbosulfan, in gills, liver, kidney and muscle of the fish. Findings from this study have demonstrated that inhibition of AChE and BuChE activity in C. mrigala is a useful biomarker in assessing the aquatic environment contaminated by anticholinesterases not only in the brain, but also in other vital organs; hence, it can be used as a biomarker for monitoring purposes.
关键词：Parathion; carbosulfan; acetylcholinesterase; butyrylcholinesterase; inhibition