文章基本信息

标题：Whole-exome sequencing data of suicide victims who had suffered from major depressive disorder
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作者：Dóra Tombácz ; Zoltán Maróti ; Tibor Kalmár 等
期刊名称：Scientific Data
电子版ISSN：2052-4463
出版年度：2019
卷号：6
DOI：10.1038/sdata.2019.10
语种：English
出版社：Nature Publishing Group
摘要：Suicide is one of the leading causes of mortality worldwide; it causes the death of more than one million patients each year. Suicide is a complex, multifactorial phenotype with environmental and genetic factors contributing to the risk of the forthcoming suicide. These factors first generally lead to mental disorders, such as depression, schizophrenia and bipolar disorder, which then become the direct cause of suicide. Here we present a high quality dataset (including processed BAM and VCF files) gained from the high-throughput whole-exome Illumina sequencing of 23 suicide victims 鈥?all of whom had suffered from major depressive disorder - and 21 control patients to a depth of at least 40-fold coverage in both cohorts. We identified ~130,000 variants per sample and altogether 442,270 unique variants in the cohort of 44 samples. To our best knowledge, this is the first whole-exome sequencing dataset from suicide victims. We expect that this dataset provides useful information for genomic studies of suicide and depression, and also for the analysis of the Hungarian population.