文章基本信息

标题：Anti-genotoxic effects of crude garlic extract on cisplatin induced toxicity on germ cells and morphology of sperms in in vivo mouse
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作者：Somisetty Anuradha ; K. Rudrama Devi
期刊名称：Journal of Cell and Animal Biology
电子版ISSN：1996-0867
出版年度：2011
卷号：5
期号：13
页码：279-282
语种：English
出版社：Academic Journals
摘要：The present investigation was directed to study the possible anti-genotoxic activity of orally administered crude garlic extract (GE) against cisplatin-induced genotoxicity in mouse by using chromosomal aberrations (CA’s) in germ cells and sperm morphology essay (SMA). Three different doses of garlic extract (125, 250, 500 mg/kg) were tested for their modulatory capacity on the mutagenecity exerted by CP (10 mg/kg, i.p.). GE alone did not induce any significant variation in the incidence of CA’s and frequency of aberrant sperms. Pretreatment of mice with GE for 7 days and simultaneously with a single dose of Cisplatin significantly reduced the frequency of CA’s and frequency of aberrant sperms, suggesting that the garlic extract modulates the CP induced genotoxicity in a dose dependent manner.
关键词：Garlic;chromosomal aberrations;germ cells