摘要:The colorless gaseous compound nitricoxide (NO) is a lipophilic free radical that diffuses readily through theplasma membrane. These attributes make nitric oxide ideal for a transientparacrine (between adjacent cells) and autocrine (within a single cell)signaling molecule. The half–life of NO in biological tissues is estimated tobe < 6 Sec. This short half–life reflects the highly reactive nature of NO.It reacts directly with metal complexes and other radicals and indirectly as areactive nitrogen oxide species with DNA, protein, and lipids. NO was firstdescribed in 1772 as nitrous air by Joseph Priestly the English theologianchemist and by co–educators. He was also the first to describe nitrous oxide (N2O), which he named nitrous airdiminished. Priestly’ nitrous air induced a sensation of mild drunkenness,often coupled with bouts of uncontrollable laughter.