文章基本信息

标题：Short-term cactus pear [ Opuntia ficus-indica (L.) Mill] fruit supplementation ameliorates the inflammatory profile and is associated with improved antioxidant status among healthy humans
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作者：Alessandro Attanzio ; Luisa Tesoriere ; Sonya Vasto 等
期刊名称：Food & Nutrition Research
印刷版ISSN：1654-661X
出版年度：2018
卷号：62
DOI：10.29219/fnr.v62.1262
语种：English
出版社：Co-Action Publishing
摘要：Background Dietary ingredients and food components are major modifiable factors protecting immune system and preventing the progression of a low-grade chronic inflammation responsible for age-related diseases. Objective Our study explored whether cactus pear ( Opuntia ficus-indica, Surfarina cultivar) fruit supplementation modulates plasma inflammatory biomarkers in healthy adults. Correlations between inflammatory parameters and antioxidant status were also assessed in parallel. Design In a randomised, 2-period (2 weekseriod), crossover, controlled-feeding study, conducted in 28 healthy volunteers [mean age 39.96 (±9.15) years, BMI 23.1 (±1.5) kg/m 2], the effects of a diet supplemented with cactus pear fruit pulp (200 g, twice a day) were compared with those of an equivalent diet with isocaloric fresh fruit substitution. Results With respect to control, cactus pear diet decreased ( p 0.05) the pro-inflammatory markers such as tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, interferon-γ (INF)-γ, IL-8, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), whereas it increased ( p 0.05) the anti-inflammatory marker IL-10. Moreover, the diet decreased ratios between pro-inflammatory biomarkers (CRP, IL-6, IL-8, TNF-α) and anti-inflammatory biomarker (IL-10) ( p 0.05). Cactus pear supplementation caused an increase ( p 0.05) in dermal carotenoids (skin carotenoid score, SCS), a biomarker of the body antioxidant status, with correlations between SCS and CRP ( r = −0.905, p 0.0001), IL-8 ( r = −0.835, p 0.0001) and IL-10 ( r = 0.889, p 0.0001). Conclusions The presently observed modulation of both inflammatory markers and antioxidant balance suggests cactus pear fruit as a novel and beneficial component to be incorporated into current healthy dietary habits.