文章基本信息

标题：Study on Synthesis of Star Poly(Îµ-caprolactone)-bpolylysineCopolymer, Characterization and ItsMicellesâ€™ Properties
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作者：Shao He-Wei ; Xue Rong ; Zeng Yong-Jun 等
期刊名称：Current Journal of Applied Science and Technology
印刷版ISSN：2457-1024
出版年度：2015
卷号：8
期号：4
页码：341-347
语种：English
出版社：Sciencedomain International
摘要：Four-armed star poly (ε-caprolactone) (PCL) terminated with carboxy group was prepared by two-step reaction. The carboxy group of star PCL was activated and chemically conjugated to the amine group of PLL (polylysine) to produce sPCL-b-PLL copolymer. The structure of final product and the intermediates were characterized by IR and 1H NMR. The sPCL-b-PLL copolymer can self-assemble into micelle in aqueous solution. The CMC (critical micelle concentration) of micelle ranged from 7.603 × 10-4 to 2.638 × 10-4 mg.mL-1 for different sPCL-b-PLL copolymer. In addition, Curcumin as a hydrophobic drug can be entrapped in the sPCL-b-PLL micelle. The results indicated that the micelle exhibited 9.431% loading capacity for Curcumin, and it can be used as a potential delivery carrier for the hydrophobic drug.
关键词：Star amphiphilic block polymer;poly (Îµ-caprolactone)-b-polylysine;biodegradablematerial;polymer micelles;curcumin