文章基本信息

标题：Disposable Microfluidic Sensor Based on Nanocellulose for Glucose Detection
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作者：Khan Mohammad Ahsan Uddin ; Ville Jokinen ; Farzin Jahangiri 等
期刊名称：Global Challenges
印刷版ISSN：2056-6646
电子版ISSN：2056-6646
出版年度：2019
卷号：3
期号：2
DOI：10.1002/gch2.201800079
语种：English
出版社：John Wiley & Sons, Ltd
摘要：AbstractPoint‐of‐care devices that are inexpensive, disposable, and environmentally friendly are becoming increasingly predominant in the field of biosensing and biodiagnostics. Here, microfluidics is a suitable option to endow portability and minimal reagent and material consumption. Nanocellulose is introduced to manufacture microfluidic channels and as a storage and immobilization compartment of glucose oxidase. Improved enzymatic activity retention is demonstrated in a simple and disposable point‐of‐care diagnostic unit that is able to detect glucose from fluid matrices at 0.1 × 10−3mconcentration and in less than 10 min. It is concluded that the patterning and fluidic technologies that are possible with nanocellulose enable easily scalable multianalyte designs.Renewable and environmental friendly nanocelluloseacts as a material for microfluidic channels and as storage for glucose oxidase enzyme immobilization for improved activity retention. A simple, enzyme based, disposable point‐of‐care diagnostics approach is designed for the detection of glucose at 0.1 × 10−3mconcentration in less than 10 min. The patterning and fluidic technologies allow concept scale‐up to multianalyte designs.
关键词：biosensorscolorimetrydiagnosticsglucose oxidasenanofibrils