Introduction: Sexual phobia can result in a lot of problems in women and their husbands. In the current study the effectiveness of cognitive-behavior therapy (CBT), drug therapy and their combination was assessed.

Method: In this experiment 13 female patients with sexual phobia were randomly divided into 3 treatment groups: 1-CBT (n=5), 2- Fluoxetine (n=3), 3- A Combination of CBT and fluoxetine (n=5). All subjects were pre- and post-tested by Measurement of Sexual Function, Irrational Beliefs Questionnaire and Sexual Anxiety Scale .Data were analyzed by t-test and ANOVA.

Results: Findings showed that CBT alone or in combination with fluoxetine was effective in re- ducing maladaptive cognitions, irrational beliefs and sexual anxiety, but treatment with fluox-etine alone was not effective.

Conclusion: Combination therapy was more effective than fluoxetine alone but it was not sig- nificantly different from CBT alone. Therefore, it seems that the improvement of patients’ sypm- toms were related to CBT alone.