文章基本信息

标题：THE INFLUENCE OF STEATOSIS AND CONJUGATEFACTORS OF RESPONSE TO ANTIVIRAL TREATMENT INCRONIC HEPATITIS C
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作者：Anca UNGUREANU ; Alice Elena GĂMAN ; Andrei Ioan DROCAȘ 等
期刊名称：Research and Science Today
印刷版ISSN：2247-4455
电子版ISSN：2285-9632
出版年度：2016
期号：1
页码：147-155
语种：English
出版社：RST Journal
摘要：HEPATITIS C VIRUS (HCV) IS A MAJOR CAUSE OF CHRONIC LIVER DISEASE WORLDWIDE. ANINCREASED PREVALENCE OF STEATOSIS IN PATIENTS WITH HCV IS WELL ESTABLISHED. MOSTSTUDIES HAVE REPORTED APPROXIMATELY 50% PREVALENCE OF STEATOSIS AMONG PATIENTSUNDERGOING A LIVER BIOPSY BECAUSE OF HCV. IN COMPARISON, AMONG PATIENTS WITHAUTOIMMUNE HEPATITIS AND HEPATITIS B (HBV), STEATOSIS IS NOT COMMONLY OBSERVED.HEPATITIS C VIRUS (HCV) INFECTION IS AN IMPORTANT RISK FACTOR FOR INSULIN RESISTANCE(IR). THE LATTER IS THE PATHOGENIC FOUNDATION UNDERLYING METABOLIC SYNDROME,STEATOSIS AND CIRRHOSIS, AND POSSIBLY HEPATOCELLULAR CARCINOMA (HCC). WHEREAS THEOVERALL PREVALENCE OF IR IS 10%-25% OF THE POPULATION, THE PREVALENCE IR IN HCVINFECTION REACHES FIGURES RANGING BETWEEN 30% TO 70%. OBESITY AND/OR STEATOSIS INPATIENTS WITH CHRONIC HCV HAS CONSISTENTLY BEEN SHOWN TO BE ASSOCIATED WITH ANIMPAIRED RESPONSE TO ANTIVIRAL TREATMENT WITH INTERFERON THERAPY. IT IS NOT CLEARWHETHER THIS ASSOCIATION BETWEEN OVERWEIGHT OR OBESITY AND POOR RESPONSE TOANTIVIRAL THERAPY IS DUE TO STEATOSIS AND MIGHT NOT ONLY BE LINKED TO OBESITY.ACCUMULATING EVIDENCE SUGGESTS THAT STEATOSIS PLAYS A ROLE IN HCV-RELATEDFIBROSIS, AND SUPPORT FOR THIS ALSO COMES FROM STUDIES SHOWING THAT WEIGHTREDUCTION IN THESE PATIENTS LEADS NOT ONLY TO A DECREASE IN STEATOSIS BUT ALSOIMPROVEMENT IN FIBROSIS SCORE.
关键词：HEPATITIS C VIRUS;STEATOSIS;NON-ALCOHOLIC FATTY LIVER;INSULIN;RESISTANCE;INTERFERON THERAPY