文章基本信息

标题：Enhanced in vitro dissolution of Iloperidone using Caesalpinia Pulcherrima mucoadhesive microspheres
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作者：Pradum Pundlikrao Ige ; Pradum Pundlikrao Ige ; Kapil Agrawal 等
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2015
卷号：4
期号：1
页码：26-32
DOI：10.1016/j.bjbas.2015.02.004
语种：English
出版社：Elsevier
摘要：AbstractsThe aim of the present investigation was to improve the solubility and dissolution rate of Iloperidone. Microspheres containing Iloperidone were prepared by spray drying using mucilage extracted from seeds ofCaesalpinia pulcherrima.The novelty of this work is that, the extraction of mucilage and its usage for preparation of drug loaded microspheres. The prepared microspheres were characterized by SEM, DSC, XRPD, FTIR,1H-NMR, particle size, drug content, entrapment efficiency,in vitrodissolution andex vivomucoadhesion. Based on particle size, drug content,ex vivomucoadhesive strength andin vitrodrug release, the best formulation was optimized. Percent entrapment efficiency and mean particle size for optimized formulation was found to be 73.49 and 3.27 ± 1.23 μm, respectively. More precisely, mucilage ofC. pulcherrimacould be significant carrier of (drug and polymer ratio 1:5) microspheres for the development of oral drug delivery.
关键词：Iloperidone;Caesalpinia pulcherrima;mucilage;Spray drying;Mucoadhesive microspheres;Solubility enhancement