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标题：A comparative in vivo and in vitro evaluation of hair growth potential of extracts and an isolate from petroleum ether extract of Cuscuta reflexa Roxb
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作者：Satish Patel ; Satish Patel ; Mukesh K. Nag 等
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2014
卷号：3
期号：3
页码：165-171
DOI：10.1016/j.bjbas.2014.10.002
语种：English
出版社：Elsevier
摘要：AbstractThis study examined the inhibitory effect of Stigmast-5-en-3-O-glucopyranosidetriacetate-51-ol (SGTA), an isolate from petroleum ether extract ofCuscuta reflexaand performed comparative study of petroleum ether extract (PTE), ethanolic extract (ETE) and SGTA on hair growth activity in androgenic alopecia rat model. Alopecia induced in albino rats by testosterone administration subcutaneously for 21 days. Finasteride solution was applied topically served as standard.In vitroexperiment to study the effect of extracts and isolate on activity of 5α-reductase enzyme and comparing with finasteride.In vivoexperiment showed that rat follicular density and anagen/telogen (A/T) ratio were increased in the PTE, ETE and SGTA treated group when compared to a control group. Skin histological results shown that the PTE, ETE and SGTA treated group had an increase in number and shape of the hair follicles and increase in the follicle anagen/telogen ratio when compared to the finasteride and control group. The result indicated that the ethanolic, petroleum ether extract and isolate of petroleum ether extract ofC. reflexafound useful in the treatment of androgen-induced alopecia in the experimental animal. In summary, SGTA and extract control the apoptosis of hair cells and retarded the testosterone induce alopecia and therefore be a natural product with much impending for use as a treatment for androgenic alopecia.
关键词：Cuscuta reflexa;Androgenetic Alopecia;Hair loss;5α-reductase;A/T ratio