文章基本信息

标题：Antioxidant, antimicrobial activity and in silico PASS prediction of Annona reticulata Linn. root extract
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作者：Prasad G. Jamkhande ; Prasad G. Jamkhande ; Amruta S. Wattamwar 等
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2014
卷号：3
期号：2
页码：140-148
DOI：10.1016/j.bjbas.2014.05.008
语种：English
出版社：Elsevier
摘要：AbstractMicrobial infections and diseases are frequently associated with several pathogenic strains of bacteria and fungi. Plants of thereticulatagenus are a notable source of new therapeutic agents including antioxidant and antimicrobial. This study reports the antioxidant and antimicrobial activities of methanolic root extract ofAnnona reticulataLinn. The antioxidant property of extract was evaluated using DPPH free radical scavenging and hydrogen peroxide assay. Antibacterial tests were performed using the agar cup method whereas Poison plate method was used to assess sensitivity of fungal strains. The biological potential of major phytoconstituents as antimicrobial agent was screened by new software based tool, PASS. The dose dependent scavenging was observed at concentrations 20, 40, 60, 80 and 100 μg/ml which were compared to ascorbic acid. The probable activity (Pa) of neoannonin using PASS was found to be 0.541. The extract was significantly active against all strains of bacteria but the largest zone of inhibition was found againstB. cereus. Predominant growth reduction was observed in fungiTricoderma virideandCandida albicans. The results indicate that the extract show potential as a source of new antimicrobial drug and may impart health benefits by its antioxidant property.
关键词：Annona reticulata;Antioxidant activity;PASS prediction;Antimicrobial activity;DPPH radical scavenging assay;H;2;O;2;assay