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标题：The determinants of hepcidin level in chronic kidney disease and hemodialysis Saudi patients
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作者：Tarek Mohamed Ali ; Tarek Mohamed Ali ; Ashraf Mahmoud Genina 等
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2014
卷号：3
期号：2
页码：133-139
DOI：10.1016/j.bjbas.2014.05.007
语种：English
出版社：Elsevier
摘要：AbstractBackgroundChronic kidney failure is associated with many kinds of metabolic changes caused by the kidney disease itself and by dialysis treatment. Chronic kidney disease (CKD) and hemodialysis patients (HD) are associated with increased serum hepcidin levels, the main regulator of iron metabolism and modulated in response to anemia, hypoxia, or inflammation.ObjectivesTo investigate the determinants of hepcidin levels in patients with CKD on conservative treatment and in hemodialysed patients.Subjects and methodsThirty healthy controls, 40 patients with CKD and 54 consecutive patients on hemodialysis were included in the study. Serum hepcidin and markers of iron status and inflammation, glycemic status including fasting blood sugar (FBS), fasting serum insulin (FSI), the lipid profile and renal function, all were assessed using standard laboratory methods. The homeostasis model assessment-insulin resistance index (HOMA-IR) was calculated. GFR was estimated using MDRD formula.ResultsIn CKD and HD patients, hepcidin was correlated to FBS, FSI, HOMA-IR and, total protein, creatinine and ferritin. eGFR was associated with hepcidin only in HD patients. In HD patients, the best predictors of hepcidin levels were serum ferritin, FBS and creatinine while in CKD patients the best predictors for hepcidin levels were serum albumin, cholesterol and HOMA-IR.ConclusionsHepcidin levels are correlated to the glycemic status in CKD and HD patients and hepcidin levels in hemodialysed patients were significantly correlated with eGFR but it is not considered as an independent predictor for hepcidin level in these patients.
关键词：Anemia;Chronic kidney disease;Glucose;Insulin resistance;Hepcidin;Iron