文章基本信息

标题：The effect of retinyl-palmitate on brain regeneration of larval Xenopus laevis
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作者：S. Bernardini ; C. Gargioli ; S. M. Cannata 等
期刊名称：The European Zoological Journal
电子版ISSN：2475-0263
出版年度：2010
卷号：77
期号：3
页码：261-271
DOI：10.1080/11250000903055154
语种：English
出版社：Taylor & Francis Group
摘要：In this work we have studied the effect of treatment with retinyl-palmitate (RP) upon brain regeneration of Xenopus laevis larvae submitted to partial removal of telencephalon, mesencephalon and cerebellum. Results demonstrated a specific inhibitory effect on brain regeneration. At the level of the telencephalon, the inhibition took place above all in the proliferative phase of the regenerative process, delaying, as a consequence, the evolution of the same process. Nevertheless, the morphogenetic phase suffered a very modest inhibition resulting in a moderate accentuation of the hypomorphosis observed in the operated controls raised in water. At the level of the cerebellum, the inhibitory action exercised by RP treatment was much greater than that observed in the telencephalon and continued not only in the proliferative phase, but also the morphogenetic phase of the regenerative process. As a result of such an inhibition, the animals treated with RP either regenerated an extremely hypomorphic cerebellum or did not regenerate at all. At the level of the mesencephalon, RP treatment did not produce a sharp inhibition of proliferative activity, but slightly influenced the morphogenesis of the regenerated optic tectum, which was thinner but more extended. In conclusion, the data of the present work demonstrate that the stem cells responsible for the regenerative processes of the larval brain have a sensitivity to retinoids that is region-specific.
关键词：Brain; regeneration; retinoids; Xenopus