文章基本信息

标题：Modelling the Central Carbon Metabolism of three Cancer Cells using 13C Data
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作者：Roman Rainer ; Edda Klipp
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2018
卷号：51
期号：19
页码：80-81
DOI：10.1016/j.ifacol.2018.09.037
语种：English
出版社：Elsevier
摘要：AbstractTen percent of all colon cancer cases have an activating KRAS mutation. Cases with this kind of mutation do not respond to the usual drug treatment. KRAS mutated colon cancer cells have an accumulation of lactate, which is a potential option as a treatment target. We build a kinetic model to compare the KRAS cell line with two other common colon cancer cell lines to investigate the reason for the accumulation of lactate. The purpose of the model is to see if the differences of their central carbon metabolism are based only on enzyme concentrations or otherwise find potential modifications in enzymes.To achieve this goal we use flux data, metabolomics data,13C metabolomics data, and proteomics data. The model tracks carbon groups in glycolysis. We use the L1 regularization to find the differences in parameters for the cell lines.
关键词：KeywordsGlycolysis13C DataColon CancerKinetic Modelling