文章基本信息

标题：Immunomodulatory activity of Lactobacillus plantarum KLDS1.0318 in cyclophosphamide-treated mice
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作者：Yueyue Meng ; Bailiang Li ; Da Jin 等
期刊名称：Food & Nutrition Research
印刷版ISSN：1654-661X
出版年度：2018
卷号：62
DOI：10.29219/fnr.v62.1296
语种：English
出版社：Co-Action Publishing
摘要：BackgroundProbiotics in fermented foods have attracted considerable attention lately as treatment options for immune diseases, the incidence of which has been increasing throughout the world.ObjectiveThe objective of the present study was to investigate the immunomodulatory activity ofLactobacillus plantarum(L. plantarum) KLDS1.0318 in cyclophosphamide-treated mice.DesignTo investigate the immune-enhancing effects ofL. plantarumKLDS1.0318, we used a immunosuppressive model. Ninety female six-week-old BALB/c mice were randomly divided into six groups: normal control (NC) group, model control (MC) group, immunosuppression plusL. plantarumKLDS1.0318 groups with three different doses (KLDS1.0318-L, KLDS1.0318-M, and KLDS1.0318-H), and plus levamisole hydrochloride as positive control (PC) group.Results and discussionsResults showed that the thymus and spleen indexes of the four treatment groups were significantly higher than those of the MC group (2.01±0.16) (pppConclusionsThis study suggested that orally administered L.plantarum KLDS1.0318 may effectively accelerate the recovery of immunosuppressive mice caused by cyclophosphamide (CTX). The immunomodulatory activity of the srtain recommended that L. plantarum KLDS1.0318 could be used as a powerful medicinal treatment against immunosuppression.