摘要:This study investigates a parameter optimization approach to maximize the specific growth rate of the Chlorella vulgaris microalgae species, its biomass productivity, and CO2 capture rate. For this purpose, the Box‐Behnken experimental design technique is applied with temperature, nitrogen to phosphorus ratio, and light‐dark cycle per day, as the growth controlling parameters. For each response, a quadratic model is developed separately describing the algal specific growth rate, biomass productivity, and CO2 capture rate, respectively. The maximum specific growth rate of 0.84 d−1 is obtained at 25 °C, with a nitrogen to phosphorus ratio of 3.4:1, and light‐dark cycles of 24/0 h. Maximum biomass productivity of 147.3 mg L−1 d−1 is found at 30 °C, with a nitrogen to phosphorus ratio of 3:1, and light‐dark cycles of 12/12 h. In addition, the maximum CO2 capture rate of 159.5 mg L−1 d−1 is also obtained at 30 °C, with a nitrogen to phosphorus ratio of 4:1, and light‐dark cycles of 23/1 h. Finally, a multi‐response optimization method is applied to maximize the specific growth rate, biomass productivity, and CO2 capture rate, simultaneously. The optimal set of 30 °C, a nitrogen to phosphorus ratio 3:1, and light‐dark cycles 16/8 h, provide the maximum specific growth rate of 0.66 per day, biomass productivity of 147.6 mg L−1 d−1, and CO2 capture rate of 141.7 mg L−1 d−1.