文章基本信息

标题：Analysis of selenium status from dried blood spots by total-reflection X-ray fluorescence analysis
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作者：Magdalena Czuban ; Magdalena Czuban ; Sarah Blasig 等
期刊名称：Perspectives in Science
印刷版ISSN：2213-0209
电子版ISSN：2213-0209
出版年度：2015
卷号：3
期号：1-4
页码：32-33
DOI：10.1016/j.pisc.2014.11.021
语种：English
出版社：Elsevier
摘要：Selenium (Se) takes a prime position for human health among the essential trace elements (Rayman, 2012). Se is not only essential for male fertility (Michaelis et al., 2014), but also for growth, differentiation and thyroid hormone metabolism (Dumitrescu et al., 2005). A severe Se deficit has been associated with subfertility, increased risk of chronic diseases including cancer, cardiovascular disease, type 2 diabetes, mostly related with oxidative stress. However, it is difficult to determine the Se status of a given individual due to the need for specialized methods and expensive instrumentations. In the clinics, congenital diseases are detected from small amounts of full blood taken shortly after birth, subsequently dried and stored on a filter paper as dried blot spots (DBS) (Vacchina et al., 2014). This technique has been meanwhile successfully adopted to different medical disciplines, from epidemiology via therapy monitoring to toxicology (Stove et al., 2012) Figure 1.