文章基本信息

标题：Kernel-based Estimate of the Insulin Action of Rapid-Acting Insulin in Home-Monitored Data
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作者：Fredrik Ståhl ; Erik Lindström ; Mona Landin Olsson 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2015
卷号：48
期号：28
页码：715-720
DOI：10.1016/j.ifacol.2015.12.214
语种：English
出版社：Elsevier
摘要：AbstractTo improve glycemic control in insulin-dependent diabetes, estimates of the glucose- lowering effect of insulin-the insulin action (IA)-and the dynamics thereof are essential. The current practice relies on generic estimates of the dynamic shape of the IA and rules-of-thumb to assess the total glucose-lowering effect. In this paper we present individualized estimates based on home-monitored data, incorporating a kernel-based estimate that also accounts for the nonlinear behavior of the IA across the glucose range. The method is successfully validated on 29 patients on continuous insulin pump therapy.
关键词：KeywordsBiomedical systemsNon-parametric identificationPhysiological modelsDiabetes