文章基本信息

标题：Prediction of Pre-microRNA Secondary Structure Based on Reverse Complementary Folding
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作者：Jin Li ; Chengzhen Xu ; Lei Wang 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2015
卷号：48
期号：28
页码：239-244
DOI：10.1016/j.ifacol.2015.12.132
语种：English
出版社：Elsevier
摘要：AbstractBased on the general features of the pre-microRNA secondary structure, this paper specifically predicts the pre-microRNA secondary structure, which focuses on the reverse complementary folding and forces them to form hairpin loop structures, this algorithm named 'rcfold'. In the result, a number of pre-microRNA sequencing data structure level as the test data set of the proposed algorithm, and then the predicted results obtained by the proposed 'rcfold' algorithm is compared with the ones acquired by rnafold. The experimental results show that in sensitivity, specificity and MCC value, the proposed algorithm outperforms rnafold.
关键词：KeywordsRNAPath planningComplementarySuboptimalStructural optimizationStructural constraints