文章基本信息

标题：Cardiac Modeling: Identification of Subject Specific Left-Ventricular Isovolumic Pressure Curves
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作者：Jonas Gesenhues ; Marc Hein ; Thivaharan Albin 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2015
卷号：48
期号：20
页码：581-586
DOI：10.1016/j.ifacol.2015.10.204
语种：English
出版社：Elsevier
摘要：AbstractIn this paper we present a mathematical model for isovolumic left-ventricular pressure curves intended for applications in computer simulation models of the cardiovascular system. We chose a quadratic spline to individually account for the specific phases of isovolumic beats. Besides, we describe a method to identify subject specific isovolumic pressure curves based on measured physiological (non-isovolumic) pressure curves. Therefore, we used experimental data obtained from a trial on an anesthetized pig. Specifically, we investigated the effect of a preload reduction for a given contractile state on the isovolumic pressure curves. Towards validation of the proposed model we compared the predicted isovolumic pressure curve to data of real experimentally obtained isovolumic beats. Besides, a comparison to alternative isovolumic pressure curve identification approaches for a different application (estimating contractility by single-beat evaluation) is drawn.
关键词：KeywordsCardiac ModelingIdentificationLeft VentricleIsovolumic ContractionPressure Curves