文章基本信息

标题：Robust Bifurcation Analysis for a Genetic Controller Design Problem for Cell Fate Control *
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作者：Hikaru Ikuta ; Masaki Inoue ; Shuichi Adachi 等
期刊名称：IFAC PapersOnLine
印刷版ISSN：2405-8963
出版年度：2015
卷号：48
期号：18
页码：53-58
DOI：10.1016/j.ifacol.2015.11.010
语种：English
出版社：Elsevier
摘要：AbstractWe propose a robustness analysis method for biomolecular controller design. First, we provide a computational method of bifurcation and robustness analysis for general nonlinear systems with dynamic uncertainties. We then apply the method to study a model that represents a genetic network system for controlling cell fates through external stimulus. In the network system, an artificial genetic controller is connected to the MAPK pathway. The proposed robust bifurcation method is used to determine design parameters of the controller for robustly achieving desired properties, in the presence of dynamic uncertainties.
关键词：KeywordsBifurcation analysisrobustness analysissynthetic biologygene regulatory networksbiomolecular systems