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标题：Lexico-semantic Impairment in a Case of HSVE to the Left Anterior Temporal Lobe
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作者：D. Roberts ; D. Roberts ; E. Hughs 等
期刊名称：Procedia - Social and Behavioral Sciences
印刷版ISSN：1877-0428
出版年度：2012
卷号：61
页码：304-306
DOI：10.1016/j.sbspro.2012.10.199
语种：English
出版社：Elsevier
摘要：This study investigates the role of the left anterior temporal lobe (aTL) in semantics. Clinical and neuroscientific investigations propose the aTL bilaterally (BaTL), are implicated in semantics, based on findings that: (1) disruption to BaTL results in a multimodal semantic impairment, observed in semantic dementia (SD) and herpes-simplex-viral-encephalitis (HSVE); (2) impairment can be mimicked by inducing a “virtual lesion” (repetitive-transcranial-magnetic-stimulation) to BaTL in neurologically intact participants; (3) neuroimaging studies identify BaTL activation for semantic tasks (Fig. 1, Lambon Ralph et al.,2012, for points 1-3). Anchored in this evidence is the assumption that semantic impairment will result from BaTL damage only. Recently, investigators have suggested a loss of semantic knowledge can result from LaTL damage. Using sensitive tests, this can be observed in chronic stroke (Schwartz et al.,2009) and temporal lobe resection for epilepsy patients (rTLE: Antonucci et al.,2008; Lambon Ralph et al.,2012). Of interest is the striking similarity of rTLE and very early stages of SD (when atrophy is left sided and overlaps with resection) - impairment is mild and the primary symptom is anomia and/or forgetfulness. This builds upon the possibility that a semantic weakness may result from a LaTL lesion. Whilst rTLE studies have provided insight into this notion, one must be cautious - pre-surgical seizures may initiate changes in brain organisation/normal development, and reorganisation of function could occur post-surgery. Chronic stroke studies are problematic since lesions are large and encompass other areas that may contribute to the impairment. Consequently, whether LaTL lesions results in semantic impairment is not entirely understood. The goal of the present case study was to initiate an investigation to determine whether semantic impairment is in fact present following LaTL lesions.