摘要:Damage to left perisylvian regions often results in phonological alexia/agraphia syndromes, which are characterized by disproportionate difficulty reading/spelling novel sequences of graphemes/phonemes (pseudowords) compared to real words. While it has been shown that these deficits can be ameliorated through behavioral therapy, the neural substrates supporting these improvements remain to be elucidated. Because phonological processing is a strongly left-lateralized skill in most literate adults, we hypothesized that neural support for improvement is likely to remain in the left hemisphere. To examine this hypothesis, we conducted pre-post treatment fMRI with an individual with acquired phonological alexia/agraphia due to left hemisphere stroke.