文章基本信息

标题：Cost-effectiveness of varicella and zoster vaccination in England&Wales: importance measures for correlated parameters
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作者：J. Bilcke ; J. Bilcke ; AJ van Hoek 等
期刊名称：Procedia - Social and Behavioral Sciences
印刷版ISSN：1877-0428
出版年度：2010
卷号：2
期号：6
页码：7611-7612
DOI：10.1016/j.sbspro.2010.05.142
语种：English
出版社：Elsevier
摘要：AbstractThis study aims to explore irregular relationships between input and outcomes in cost-effectiveness analysis, accounting for interdependencies between many input parameters. We used a dynamic infectious disease transmission model investigating the cost-effectiveness of varicella and zoster vaccination as a case study. Incremental costs and effects were used separately as the outcomes of interest, rather than the ratio between these, and a single R2was calculated for groups of interdependent input parameters. Partial R2was obtained as measure for the marginal proportion of variance explained. The most important input parameters were related to zoster epidemiology and disease transmission. In case of linear relationships, R2is an easy to obtain importance measure, also in the presence of interdependent input parameters.
关键词：coefficient of determination;correlation;dependency;sensitivity measure;uncertainty;cost-effectiveness