文章基本信息

标题：Evaluation of the epidural analgesic effect of Nalbuphine, Lidocaine and Nalbuphine-Lidocaine combination in bucks
本地全文：下载
作者：G.A. Ragab ; G.A. Ragab ; M.Z. Fathy 等
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2018
卷号：7
期号：1
页码：27-30
DOI：10.1016/j.bjbas.2017.07.001
语种：English
出版社：Elsevier
摘要：AbstractNalbuphine is a lipophilic opioid which could be used subcutaneously, intramuscularly, intravenously and epidurally in human, dogs and equine but not used in bucks until yet. The aim of the existing study was to compare the analgesic effect of Nalbuphine,Lidocaine and Nalbuphine-Lidocaine combination injected epidurally in bucks. Fifteen adult apparently healthy bucks were used. The animals were randomly divided into three groups (five animals in each one); group (1) was injected with Nalbuphine HCl at a dose 3mg/kg, group (2) was injected with Lidocaine HCl 2% at a dose 2.5mg/kg. Finally, group (3) was injected with Nalbuphine-Lidocaine combination at a dose (1.5mg/kg and 1.25mgkg, resp.) to evaluate the analgesic effect of each treatment. Onset and duration of analgesia were recorded after each treatment. Respiratory rate, heart rate, rectal temperature and biochemical parameters were recorded for each treatment. The results revealed that, the onset and duration of analgesia respectively were 12±2min and 200±4min in group (1), 6±1min and 80±3 min in group (2) and 8±2min and 120±5min in group (3). In Nalbuphine group, No ataxia was observed while mild ataxia was observed in Nalbuphine-Lidocaine combination group but in Lidocaine treated group, sever ataxia was recorded. Heart rate increased at 90–120 and respiratory rate rectal temperature had no any significantly differentiation from baseline of any treatment. Biochemical parameters returned to basal levels through three hours after all treatments. In conclusion, Nalbuphine-Lidocaine combination is useful to perform surgical operations of long duration and had effective analgesia in bucks.
关键词：Epidural;Nalbuphine;Lidocaine;Bucks