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标题：Antimicrobial and cytotoxic comparative study of different extracts of Omani and Sudanese Gum acacia
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作者：Said Musallam Al Alawi ; Said Musallam Al Alawi ; Mohammad Amzad Hossain 等
期刊名称：Beni-Suef University Journal of Basic and Applied Sciences
印刷版ISSN：2314-8535
电子版ISSN：2314-8543
出版年度：2018
卷号：7
期号：1
页码：22-26
DOI：10.1016/j.bjbas.2017.10.007
语种：English
出版社：Elsevier
摘要：AbstractGum acacia, known asGum Arabicin Oman is widely grown all over the tropical countries including Gulf region. The antimicrobial and cytotoxic activities of different polarity organic extracts of Omani and SudaneseGum acacialatex has been investigated in this study using maceration method. Both Omani and SudaneseGum acacialatex samples were used to prepare different fractions using various organic solvents. The antimicrobial activity of different organic extracts was determined through disc diffusion method against clinically isolated bacterial strains. The isolated pathogenic bacterial strain are Gram (+)Staphylococcus aureus(S. aureus, Code No. 659), Gram (−)Escherichia coli(E. coli, Code No. 846), Gram (−)Escherichia coli(E. coli, Code No. 683) and Gram (−)Klebsiella pneumoniae(Code No. 684). The antibiotic levofloxacin and dimethyl sulphoxide (DMSO) were used as positive and negative controls. The cytotoxic activity of the above mentioned organic extracts was determined by brine shrimp lethality method (BSL). Both latex samples of various polarity organic extracts at different concentrations showed antimicrobial activity against the isolated human bacterial strains with an inhibition range of 0–15 mm. However, both latex samples did not reveal a significant cytotoxic activity at any concentration. In conclusion, the organic extracts from both types ofGum acacia(Omani and Sudanese) represent a good source of natural antibiotic for the treatment of various infectious diseases.
关键词：Gum acacia;Maceration;Antimicrobial activity;Cytotoxic activity;Disc diffusion method;Brine shrimp method